Ávirkan Ethanols á upptøkuna av heilivágum úr magaviljaveitini hjá rottum

Abstract

The absorption from the stomach and small intestine of some drugs with different physico-chemical properties was studied in rats, under the influence of ethanol. This was administered either together with the drugs, or was present in the organism in a steady concentration during the time of absorption. Ethanol was found capable of significantly enhancing the drug absorption from the stomach. This, however, only applied to drugs, which are absorbed fairly well even without ethanol, because of their degree of ionization and lipoid solubility at the pH of the stomach. It was shown that this positive effect of ethanol was due to
an enhanced blood supply to the gastric mucosa. When administered in concentrations higher than 10 %> (w/v), this positiv effect of ethanol was again abolished, because of its irritating effect on the gastric mucosa. By the method used, ethanol was shown to be without any influence on the absorption from the small intestine. This is considered to be due to the presence of near optimal conditions for absorption at this site. In this publication in contrast to an earlier one on the same subject (Magnussen 1968), the significance of the results in the practical life are discussed in details.